A Group M Consensus Envelope Glycoprotein Induces Antibodies That Neutralize Subsets of Subtype B and C HIV-1 Primary Viruses

HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity, and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wildtype (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes

Caregiver-assisted coping skills training for patients with COPD: background, design, and methodological issues for the INSPIRE-II study

Chronic Obstructive Pulmonary Disease (COPD) is a progressive illness characterized by airflow obstruction and dyspnea that afflicts over 12 million people and represents a leading cause of death in the United States. Not surprisingly, COPD is often associated with emotional distress and reduced psychosocial adjustment, which can negatively impact physical functioning and impair quality of life. However, the psychosocial consequences of COPD remain largely untreated. A previous randomized trial from our research team demonstrated that coping skills training (CST) can improve pulmonary-specific quality of life among pulmonary patients awaiting lung transplant (the INSPIRE study). To date, however, no studies have examined the effects of a caregiver-assisted CST intervention in patients with COPD with less severe disease

What Might Have Been Lost

This article examines the role of “independent” folk music (indie-folk) in personal identity formation. It builds upon Paul Ricoeur’s theory of narrative identity, which argues (i) that it is through the mechanism of narrative that people build a more or less coherent life-story, and (ii) emphasizes the role of art (most notably literary fiction and poetry) as a mediator in the comprehension and regulation of transitory life experiences. This article aims to apply these insights to studying the role of indie-folk, a narrative art form adhering to the traditional understanding of folk music as a genre rooted in oral tradition, in the construction of personal identity. Studying the daily use of indie-folk songs by audience members through in-depth interviewing, it shows that (i) the reception of indie-folk music results in ritualistic listening behavior aimed at coping with the experience of accelerating social time; (ii) that respondents use indie-folk narratives as resources for reading the self, and (iii) that indie-folk songs provide healing images that are effective in coping with the experience of narrated time as discordant. In arguing for the central role of narrative in identity formation, this article aims to contribute to existing research on music as a “technology of the self” (DeNora). It specifically emphasizes how narrative particles are tools and building blocks in identity construction, a process characterized by the oscillation between narrative coherence and disruption